Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms

Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms

Transcriptional enhancers are known to regulate transcript production. Here, the authors show that transcription factors that bind to enhancers also regulate polyadenylation site cleavage activity, thus changing expression of alternative 3’ UTRs.

Bibliographic Details
Main Authors: Buki Kwon, Mervin M. Fansler, Neil D. Patel, Jihye Lee, Weirui Ma, Christine Mayr
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30525-y

Internet

https://doi.org/10.1038/s41467-022-30525-y

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