Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms
Transcriptional enhancers are known to regulate transcript production. Here, the authors show that transcription factors that bind to enhancers also regulate polyadenylation site cleavage activity, thus changing expression of alternative 3’ UTRs.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30525-y |
| _version_ | 1828320818340298752 |
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| author | Buki Kwon Mervin M. Fansler Neil D. Patel Jihye Lee Weirui Ma Christine Mayr |
| author_facet | Buki Kwon Mervin M. Fansler Neil D. Patel Jihye Lee Weirui Ma Christine Mayr |
| author_sort | Buki Kwon |
| collection | DOAJ |
| description | Transcriptional enhancers are known to regulate transcript production. Here, the authors show that transcription factors that bind to enhancers also regulate polyadenylation site cleavage activity, thus changing expression of alternative 3’ UTRs. |
| first_indexed | 2024-04-13T18:17:20Z |
| format | Article |
| id | doaj.art-c243a4bae9f044088d21f66806728608 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T18:17:20Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c243a4bae9f044088d21f668067286082022-12-22T02:35:38ZengNature PortfolioNature Communications2041-17232022-05-0113111410.1038/s41467-022-30525-yEnhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoformsBuki Kwon0Mervin M. Fansler1Neil D. Patel2Jihye Lee3Weirui Ma4Christine Mayr5Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer CenterCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer CenterCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer CenterCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer CenterCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer CenterCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer CenterTranscriptional enhancers are known to regulate transcript production. Here, the authors show that transcription factors that bind to enhancers also regulate polyadenylation site cleavage activity, thus changing expression of alternative 3’ UTRs.https://doi.org/10.1038/s41467-022-30525-y |
| spellingShingle | Buki Kwon Mervin M. Fansler Neil D. Patel Jihye Lee Weirui Ma Christine Mayr Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms Nature Communications |
| title | Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms |
| title_full | Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms |
| title_fullStr | Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms |
| title_full_unstemmed | Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms |
| title_short | Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms |
| title_sort | enhancers regulate 3 end processing activity to control expression of alternative 3 utr isoforms |
| url | https://doi.org/10.1038/s41467-022-30525-y |
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