Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6

Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6

Cholesterol biosynthesis is a highly regulated pathway, with over 20 enzymes controlled at the transcriptional and posttranslational levels. While some enzymes remain stable, increased sterol levels can trigger degradation of several synthesis enzymes via the ubiquitin-proteasome system. Of note, we...

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Bibliographic Details
Main Authors: Lydia Qian, Nicola A. Scott, Isabelle M. Capell-Hattam, Eliza A. Draper, Nicole M. Fenton, Winnie Luu, Laura J. Sharpe, Andrew J. Brown
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Lipid Research
Subjects:
posttranslational regulation
cholesterol biosynthesis
cholesterol metabolism
lipids
molecular biology
SC4MOL
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523000354

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http://www.sciencedirect.com/science/article/pii/S0022227523000354

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