α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice

α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice

Abstract Extraction of α-Synuclein (αSyn) aggregates from Lewy body disease (LBD) brains has been widely described yet templated fibrillization of LB-αSyn often fails to propagate its structural and functional properties. We recently demonstrated that aggregates amplified from LB-αSyn (ampLB) show d...

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Bibliographic Details
Main Authors: Norihito Uemura, Nicholas P. Marotta, Jahan Ara, Emily S. Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin C. Luk, John Q. Trojanowski, Virginia M.-Y. Lee
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42705-5

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https://doi.org/10.1038/s41467-023-42705-5

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