Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer

Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer

Expression of the tumor-associated glycan Tn antigen (αGalNAc-Ser/Thr) has been correlated to poor prognosis and metastasis in multiple cancer types. However, the exact mechanisms exerted by Tn antigen to support tumor growth are still lacking. One emerging hallmark of cancer is evasion of immune de...

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Bibliographic Details
Main Authors: Lenneke A. M. Cornelissen, Athanasios Blanas, Anouk Zaal, Joost C. van der Horst, Laura J. W. Kruijssen, Tom O’Toole, Yvette van Kooyk, Sandra J. van Vliet
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
O-glycosylation
Tn antigen
anti-tumor immunity
tumor growth
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01622/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01622/full

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