The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson’s Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells

The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson’s Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells

Parkinson’s disease (PD) and multiple system atrophy (MSA) are caused by two distinct strains of disease-associated α-synuclein (αSyn<sup>D</sup>). Recently, we have shown that olfactory mucosa (OM) samples of patients with PD and MSA can seed the aggregation of recombinant α-synuclein b...

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Bibliographic Details
Main Authors: Chiara Maria Giulia De Luca, Alessandra Consonni, Federico Angelo Cazzaniga, Edoardo Bistaffa, Giuseppe Bufano, Giorgia Quitarrini, Luigi Celauro, Giuseppe Legname, Roberto Eleopra, Fulvio Baggi, Giorgio Giaccone, Fabio Moda
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
RT-QuIC
olfactory mucosa
α-synuclein
Parkinson’s disease
multiple system atrophy
strains
Online Access:https://www.mdpi.com/2073-4409/11/1/87

Internet

https://www.mdpi.com/2073-4409/11/1/87

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