Switching on p53: an essential role for protein phosphorylation?
The p53 tumour suppressor protein coordinates widespread changes in gene expression in response to a range of stress stimuli. p53 is regulated primarily through ubiquitylation and protein turnover mediated by its transcriptional target, MDM2. Induction and activation of p53 is achieved largely throu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Pensoft Publishers
2013-04-01
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| Series: | BioDiscovery |
| Online Access: | https://biodiscovery.pensoft.net/article/8946/download/pdf/ |