Strong ubiquitous micro-promoters for recombinant adeno-associated viral vectors

Strong ubiquitous micro-promoters for recombinant adeno-associated viral vectors

Significant progress has been made in developing recombinant adeno-associated virus (rAAV) for clinical gene therapy. While rAAV is a versatile gene delivery platform, its packaging limit of 4.7 kb limits the diseases it can target. Here, we report two unusually small promoters that enable the expre...

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Bibliographic Details
Main Authors: Sunghee Chai, Leslie Wakefield, Mason Norgard, Bin Li, David Enicks, Daniel L. Marks, Markus Grompe
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
adeno-associated virus
gene therapy
micro-promoter
universal promoter
inverted terminal repeat
AAV packaging
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012300075X

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http://www.sciencedirect.com/science/article/pii/S232905012300075X

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