Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori

Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori

Helicobacter pylori infects more than 50% of the worldwide population. It is mostly found deep in the gastric mucus lining of the stomach, being a major cause of peptic ulcers and gastric adenocarcinoma. To face the increasing resistance of H. pylori to antibiotics, antimicrobial nucleic acid mimics...

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Bibliographic Details
Main Authors: Rita S Santos, George R Dakwar, Ranhua Xiong, Katrien Forier, Katrien Remaut, Stephan Stremersch, Nuno Guimarães, Sílvia Fontenete, Jesper Wengel, Marina Leite, Céu Figueiredo, Stefaan C De Smedt, Kevin Braeckmans, Nuno F Azevedo
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
fluorescence in situ hybridization
Helicobacter pylori
locked nucleic acid
native gastric mucus
2’-OMethyl RNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300555

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http://www.sciencedirect.com/science/article/pii/S2162253116300555

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