Targeting HGF/c-Met Axis Decreases Circulating Regulatory T Cells Accumulation in Gastric Cancer Patients

Targeting HGF/c-Met Axis Decreases Circulating Regulatory T Cells Accumulation in Gastric Cancer Patients

Elucidating mechanisms involved in tumor-induced immunosuppression is of great interest since it could help to improve cancer immunotherapy efficacy. Here we show that Hepatocyte Growth Factor (HGF), a pro-tumoral and proangiogenic factor, and its receptor c-Met are involved in regulatory T cells (T...

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Bibliographic Details
Main Authors: Juliette Palle, Laure Hirsch, Alexandra Lapeyre-Prost, David Malka, Morgane Bourhis, Simon Pernot, Elie Marcheteau, Thibault Voron, Florence Castan, Ariane Lacotte, Nadine Benhamouda, Corinne Tanchot, Eric François, François Ghiringhelli, Christelle de la Fouchardière, Aziz Zaanan, Eric Tartour, Julien Taieb, Magali Terme
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cancers
Subjects:
hepatocyte growth factor
c-Met
pro-angiogenic factor
regulatory T cells
gastric cancer
targeted therapies
Online Access:https://www.mdpi.com/2072-6694/13/21/5562

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https://www.mdpi.com/2072-6694/13/21/5562

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