Targeted brain delivery of RVG29‐modified rifampicin‐loaded nanoparticles for Alzheimer's disease treatment and diagnosis

Targeted brain delivery of RVG29‐modified rifampicin‐loaded nanoparticles for Alzheimer's disease treatment and diagnosis

Abstract Alzheimer's disease (AD) is an aging‐related neurodegenerative disease. The main pathological features of AD are β‐amyloid protein (Aβ) deposition and tau protein hyperphosphorylation. Currently, there are no effective drugs for the etiological treatment of AD. Rifampicin (RIF) is a se...

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Bibliographic Details
Main Authors: Ruiyi Zhou, Lihong Zhu, Zhaohao Zeng, Rixin Luo, Jiawei Zhang, Rui Guo, Lei Zhang, Qunying Zhang, Wei Bi
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:Bioengineering & Translational Medicine
Subjects:
Alzheimer's disease
blood–brain barrier
brain targeting
MRI
rifampicin
β‐amyloid plaques
Online Access:https://doi.org/10.1002/btm2.10395

Internet

https://doi.org/10.1002/btm2.10395

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