A linked physiologically based pharmacokinetic model for hydroxychloroquine and metabolite desethylhydroxychloroquine in SARS‐CoV‐2(−)/(+) populations

A linked physiologically based pharmacokinetic model for hydroxychloroquine and metabolite desethylhydroxychloroquine in SARS‐CoV‐2(−)/(+) populations

Abstract Hydroxychloroquine (HCQ) is Food and Drug Administration (FDA)‐approved for malaria, systemic and chronic discoid lupus erythematosus, and rheumatoid arthritis. Because HCQ has a proposed multimodal mechanism of action and a well‐established safety profile, it is often investigated as a rep...

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Bibliographic Details
Main Authors: Claire Steinbronn, Yashpal S. Chhonker, Jenell Stewart, Hannah Leingang, Kate B. Heller, Meighan L. Krows, Michael Paasche‐Orlow, Anna Bershteyn, Helen C. Stankiewicz Karita, Vaidehi Agrawal, Miriam Laufer, Raphael Landovitz, Mark Wener, Daryl J. Murry, Christine Johnston, Ruanne V. Barnabas, Samuel L. M. Arnold
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.13527

Internet

https://doi.org/10.1111/cts.13527

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