Effects of low-doses of methamphetamine on d-fenfluramine-induced head-twitch response (HTR) in mice during ageing and c-fos expression in the prefrontal cortex

Abstract Background The head-twitch response (HTR) in mice is considered a behavioral model for hallucinogens and serotonin 5-HT2A receptor function, as well as Tourette syndrome in humans. It is mediated by 5-HT2A receptor agonists such as ( ±)− 2,5-dimethoxy-4-iodoamphetamine (DOI) in the prefront...

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Bibliographic Details
Main Authors: Yina Sun, Seetha Chebolu, Stone Skegrud, Setareh Kamali, Nissar A. Darmani
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Neuroscience
Subjects:
Online Access:https://doi.org/10.1186/s12868-022-00766-0