Substituted salicylic acid analogs offer improved potency against multidrug-resistant Neisseria gonorrhoeae and good selectivity against commensal vaginal bacteria

Abstract Drug-resistant Neisseria gonorrhoeae represents a major threat to public health; without new effective antibiotics, untreatable gonococcal infections loom as a real possibility. In a previous drug-repurposing study, we reported that salicylic acid had good potency against azithromycin-resis...

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Bibliographic Details
Main Authors: Hanan Almolhim, Ahmed E. M. Elhassanny, Nader S. Abutaleb, Abdallah S. Abdelsattar, Mohamed N. Seleem, Paul R. Carlier
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-41442-5