Acid-Switchable Synthesis of Trifluoromethylated Triazoles and Isoxazoles via Reaction of CF<sub>3</sub>-Ynones with NaN<sub>3</sub>: DFT Study of the Reaction Mechanism

Acid-Switchable Synthesis of Trifluoromethylated Triazoles and Isoxazoles via Reaction of CF<sub>3</sub>-Ynones with NaN<sub>3</sub>: DFT Study of the Reaction Mechanism

A detailed study of the reaction of CF<sub>3</sub>-ynones with NaN<sub>3</sub> was performed. It was found that the reaction permits the selective synthesis of either 4-trifluoroacetyltriazoles or 5-CF<sub>3</sub>-isoxazoles. The chemoselectivity of the reaction w...

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Bibliographic Details
Main Authors: Vasiliy M. Muzalevskiy, Zoia A. Sizova, Mikhail S. Nechaev, Valentine G. Nenajdenko
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
CF<sub>3</sub>-ynones
sodium azide
triazoles
isoxazoles
CF<sub>3</sub>-group
Online Access:https://www.mdpi.com/1422-0067/23/23/14522

Internet

https://www.mdpi.com/1422-0067/23/23/14522

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