RBM20, a Therapeutic Target to Alleviate Myocardial Stiffness via Titin Isoforms Switching in HFpEF

RBM20, a Therapeutic Target to Alleviate Myocardial Stiffness via Titin Isoforms Switching in HFpEF

Increased myocardial stiffness is critically involved in heart diseases with impaired cardiac compliance, especially heart failure with preserved ejection fraction (HFpEF). Myocardial stiffness mainly derives from cardiomyocyte- and extracellular matrix (ECM)-derived passive stiffness. Titin, a majo...

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Bibliographic Details
Main Authors: Na Li, Weijian Hang, Hongyang Shu, Ning Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
RNA binding motif protein 20
titin
myocardial stiffness
heart failure with preserved ejection fraction
splicing factors
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.928244/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.928244/full

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