Functional characterisation and drug target validation of a mitotic kinesin-13 in Trypanosoma brucei.
Mitotic kinesins are essential for faithful chromosome segregation and cell proliferation. Therefore, in humans, kinesin motor proteins have been identified as anti-cancer drug targets and small molecule inhibitors are now tested in clinical studies. Phylogenetic analyses have assigned five of the a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2010-08-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC2924347?pdf=render |