Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex

Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex

Unwanted RNA transcripts are targeted for degradation by nuclear complexes such as MTREC/PAXT. Here, the authors structurally and functionally characterized three interfaces of the scaffold protein Red1, providing mechanistic insights into conserved features of MTREC/PAXT architecture.

Bibliographic Details
Main Authors: Anne-Emmanuelle Foucher, Leila Touat-Todeschini, Ariadna B. Juarez-Martinez, Auriane Rakitch, Hamida Laroussi, Claire Karczewski, Samira Acajjaoui, Montserrat Soler-López, Stephen Cusack, Cameron D. Mackereth, André Verdel, Jan Kadlec
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32542-3

Internet

https://doi.org/10.1038/s41467-022-32542-3

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