Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex
Unwanted RNA transcripts are targeted for degradation by nuclear complexes such as MTREC/PAXT. Here, the authors structurally and functionally characterized three interfaces of the scaffold protein Red1, providing mechanistic insights into conserved features of MTREC/PAXT architecture.
Bibliographic Details
| Main Authors: |
Anne-Emmanuelle Foucher,
Leila Touat-Todeschini,
Ariadna B. Juarez-Martinez,
Auriane Rakitch,
Hamida Laroussi,
Claire Karczewski,
Samira Acajjaoui,
Montserrat Soler-López,
Stephen Cusack,
Cameron D. Mackereth,
André Verdel,
Jan Kadlec |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-32542-3
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