Lactate oxidative phosphorylation by annulus fibrosus cells: evidence for lactate-dependent metabolic symbiosis in intervertebral discs

Lactate oxidative phosphorylation by annulus fibrosus cells: evidence for lactate-dependent metabolic symbiosis in intervertebral discs

Abstract Background Intervertebral disc degeneration contributes to low back pain. The avascular intervertebral disc consists of a central hypoxic nucleus pulpous (NP) surrounded by the more oxygenated annulus fibrosus (AF). Lactic acid, an abundant end-product of NP glycolysis, has long been viewed...

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Bibliographic Details
Main Authors: Dong Wang, Robert Hartman, Chao Han, Chao-ming Zhou, Brandon Couch, Matias Malkamaki, Vera Roginskaya, Bennett Van Houten, Steven J. Mullett, Stacy G. Wendell, Michael J. Jurczak, James Kang, Joon Lee, Gwendolyn Sowa, Nam Vo
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Arthritis Research & Therapy
Subjects:
Lactate
Lactic acid
Intervertebral disc
Annulus fibrosus
Nucleus pulpous
Glycolysis
Online Access:https://doi.org/10.1186/s13075-021-02501-2

Internet

https://doi.org/10.1186/s13075-021-02501-2

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