A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin

A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin

Abstract Shiga toxin (Stx), a major virulence factor of enterohemorrhagic Escherichia coli (EHEC), can cause fatal systemic complications. Recently, we identified a potent inhibitory peptide that binds to the catalytic A-subunit of Stx. Here, using biochemical structural analysis and X-ray crystallo...

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Bibliographic Details
Main Authors: Miho Watanabe-Takahashi, Miki Senda, Ryunosuke Yoshino, Masahiro Hibino, Shinichiro Hama, Tohru Terada, Kentaro Shimizu, Toshiya Senda, Kiyotaka Nishikawa
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15316-1

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https://doi.org/10.1038/s41598-022-15316-1

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