Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate

ABSTRACT Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging coronavirus infecting humans that is associated with acute pneumonia, occasional renal failure, and a high mortality rate and is considered a threat to public health. The construction of a full-length infectious cDNA clo...

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Bibliographic Details
Main Authors: Fernando Almazán, Marta L. DeDiego, Isabel Sola, Sonia Zuñiga, Jose L. Nieto-Torres, Silvia Marquez-Jurado, German Andrés, Luis Enjuanes
Format: Article
Language:English
Published: American Society for Microbiology 2013-11-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00650-13