Serendipitous Discovery of a Competitive Inhibitor of FraB, a <i>Salmonella</i> Deglycase and Drug Target

Serendipitous Discovery of a Competitive Inhibitor of FraB, a <i>Salmonella</i> Deglycase and Drug Target

Although salmonellosis, an infectious disease, is a significant global healthcare burden, there are no <i>Salmonella</i>-specific vaccines or therapeutics for humans. Motivated by our finding that FraB, a <i>Salmonella</i> deglycase responsible for fructose-asparagine catabol...

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Bibliographic Details
Main Authors: Pankajavalli Thirugnanasambantham, Sravya Kovvali, Austin Cool, Yuan Gao, Anice Sabag-Daigle, Erin F. Boulanger, Mark Mitton-Fry, Angela Di Capua, Edward J. Behrman, Vicki H. Wysocki, Steffen Lindert, Brian M. M. Ahmer, Venkat Gopalan
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pathogens
Subjects:
<i>Salmonella</i> deglycase
drug discovery
competitive inhibitor
serendipity
Online Access:https://www.mdpi.com/2076-0817/11/10/1102

Internet

https://www.mdpi.com/2076-0817/11/10/1102

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