Recent Advances in Metal-Free Peptide Stapling Strategies

Protein–protein interactions (PPIs) pose challenges for intervention through small molecule drugs, protein drugs, and linear peptides due to inherent limitations such as inappropriate size, poor stability, and limited membrane penetrance. The emergence of stapled α-helical peptides presents a promis...

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Bibliographic Details
Main Authors: Wanglin Zhan, Hongliang Duan, Chengxi Li
Format: Article
Language:English
Published: American Chemical Society 2024-06-01
Series:Chem & Bio Engineering
Online Access:https://doi.org/10.1021/cbe.3c00123