Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 Gene

Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 Gene

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19) that has caused a pandemic with millions of human infections. There continues to be a pressing need to develop potential therapies and vaccines to inhibit SARS-CoV-2 infectio...

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Bibliographic Details
Main Authors: Nikesh Tailor, Bryce M. Warner, Bryan D. Griffin, Kevin Tierney, Estella Moffat, Kathy Frost, Robert Vendramelli, Anders Leung, Marnie Willman, Sylvia P. Thomas, Yanlong Pei, Stephanie A. Booth, Carissa Embury-Hyatt, Sarah K. Wootton, Darwyn Kobasa
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Viruses
Subjects:
SARS-CoV-2
COVID-19
pandemic
angiotensin-converting enzyme 2 (ACE2)
virology
infection
Online Access:https://www.mdpi.com/1999-4915/15/1/85

Internet

https://www.mdpi.com/1999-4915/15/1/85

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