Network Pharmacology-Based Prediction and Verification of Ginsenoside Rh2-Induced Apoptosis of A549 Cells via the PI3K/Akt Pathway

Network Pharmacology-Based Prediction and Verification of Ginsenoside Rh2-Induced Apoptosis of A549 Cells via the PI3K/Akt Pathway

Ginsenoside Rh2 (G-Rh2), a rare protopanaxadiol (PPD)-type triterpene saponin, from Panax ginseng has anti-proliferation, anti-invasion, and anti-metastatic activity. However, the mechanisms by which G-Rh2 induces apoptosis of lung cancer cells are unclear. In the present work, a G-Rh2 target-lung c...

Full description

Bibliographic Details
Main Authors: Chao Song, Yue Yuan, Jing Zhou, Ziliang He, Yeye Hu, Yuan Xie, Nan Liu, Lei Wu, Ji Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
ginsenoside Rh2
network pharmacology
lung cancer
A549 cells
PI3K-Akt signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.878937/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.878937/full

Similar Items