Double-Blind Placebo-Controlled Pilot Investigation of the Safety of a Single Dose of Rapid-Acting Intranasal Insulin in Down Syndrome

Abstract Background Individuals with Down syndrome are likely to develop clinical and neuropathological brain changes resembling Alzheimer’s disease dementia by the ages of 35–40 years. Intranasal insulin is a potential treatment for neurodegenerative disease that has been shown to reduce amyloid pl...

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Bibliographic Details
Main Authors: Michael Rosenbloom, Terry Barclay, Justin Johnsen, Lauren Erickson, Aleta Svitak, Maria Pyle, William Frey, Leah R. Hanson
Format: Article
Language:English
Published: Adis, Springer Healthcare 2020-02-01
Series:Drugs in R&D
Online Access:https://doi.org/10.1007/s40268-020-00296-2