Development and validation of an LC–MS/MS method for the simultaneous quantification of milbemycin oxime and praziquantel in plasma: application to a pharmacokinetic study in cats

Development and validation of an LC–MS/MS method for the simultaneous quantification of milbemycin oxime and praziquantel in plasma: application to a pharmacokinetic study in cats

IntroductionMilbemycin oxime (MBO) and praziquantel (PZQ) have a broad spectrum of biological activity and are commonly used to treat the parasitic infection in the veterinary clinic. In this study, a fast and efficient LC-MS/MS method was established and validated for the simultaneous determination...

Full description

Bibliographic Details
Main Authors: Shiting Xie, Yixing Lu, Jun Wang, Changcheng Lin, Peiyu Ye, Xiaolin Liu, Wenguang Xiong, Zhenling Zeng, Dongping Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Veterinary Science
Subjects:
milbemycin oxime
praziquantel
LC–MS/MS
cat plasma
pharmacokinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2023.1285932/full

Internet

https://www.frontiersin.org/articles/10.3389/fvets.2023.1285932/full

Similar Items