miRNA Genetic Variants Alter Their Secondary Structure and Expression in Patients With RASopathies Syndromes

miRNA Genetic Variants Alter Their Secondary Structure and Expression in Patients With RASopathies Syndromes

RASopathies are a group of rare genetic diseases caused by germline mutations in genes involved in the RAS–mitogen-activated protein kinase (RAS-MAPK) pathway. Whole-exome sequencing (WES) is a powerful approach for identifying new variants in coding and noncoding DNA sequences, including miRNAs. mi...

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Bibliographic Details
Main Authors: Joseane Biso de Carvalho, Guilherme Loss de Morais, Thays Cristine dos Santos Vieira, Natana Chaves Rabelo, Juan Clinton Llerena, Sayonara Maria de Carvalho Gonzalez, Ana Tereza Ribeiro de Vasconcelos
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Genetics
Subjects:
whole-exome-sequencing
miRNA
variants
RAS-MAPK
RASopathies
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01144/full

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https://www.frontiersin.org/article/10.3389/fgene.2019.01144/full

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