Trichostatin A destabilizes HIF-2α through a VHL-independent but proteasome-dependent pathway in cancer cell lines and tumor xenografts

Trichostatin A destabilizes HIF-2α through a VHL-independent but proteasome-dependent pathway in cancer cell lines and tumor xenografts

Histone deacetylase (HDACs) inhibitors are a new generation of anti-cancer agents. Little is known regarding the effect of HDAC inhibitors on HIF-2α. The effect of trichostatin A (TSA), a class I/II HDAC inhibitor, on HIF-2α protein expression was investiagted in cancer cell lines and tumor xenograf...

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Bibliographic Details
Main Authors: Qingcheng Yang, Yuzhen Du, Dongdong Cheng, Zhichang Zhang, Xinhui Du
Format: Article
Language:English
Published: Bangladesh Pharmacological Society 2013-03-01
Series:Bangladesh Journal of Pharmacology
Subjects:
Cancer cell line
HIF-2α
Proteasome
Trichostatin A
Tumor xenograft
VHL
Online Access:https://www.banglajol.info/index.php/BJP/article/view/13842

Internet

https://www.banglajol.info/index.php/BJP/article/view/13842

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