A combined treatment regimen of MGMT-modified γδ T cells and temozolomide chemotherapy is effective against primary high grade gliomas

A combined treatment regimen of MGMT-modified γδ T cells and temozolomide chemotherapy is effective against primary high grade gliomas

Abstract Chemotherapeutic drugs such as the alkylating agent Temozolomide (TMZ), in addition to reducing tumor mass, can also sensitize tumors to immune recognition by transient upregulation of multiple stress induced NKG2D ligands (NKG2DL). However, the potential for an effective response by innate...

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Bibliographic Details
Main Authors: Lawrence S. Lamb, Larisa Pereboeva, Samantha Youngblood, G. Yancey Gillespie, L. Burton Nabors, James M. Markert, Anindya Dasgupta, Catherine Langford, H. Trent Spencer
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-00536-8

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https://doi.org/10.1038/s41598-021-00536-8

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