Apigetrin-enriched Pulmeria alba extract prevents assault of STZ on pancreatic β-cells and neuronal oxidative stress with concomitant attenuation of tissue damage and suppression of inflammation in the brain of diabetic rats

Apigetrin-enriched Pulmeria alba extract prevents assault of STZ on pancreatic β-cells and neuronal oxidative stress with concomitant attenuation of tissue damage and suppression of inflammation in the brain of diabetic rats

In the present study, in vitro, in vivo, and in silico models were used to evaluate the therapeutic potential of Pulmeria alba methanolic (PAm) extract, and we identified the major phytocompound, apigetrin. Our in vitro studies revealed dose-dependent increased glucose uptake and inhibition of α-amy...

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Bibliographic Details
Main Authors: Tawakaltu Abdulrasheed-Adeleke, Bashir Lawal, Eyuwa Ignatius Agwupuye, Yucheng Kuo, Amarachi Mary Eni, Okwukwe Faith Ekoh, Halimat Yusuf Lukman, Amos S. Onikanni, Femi Olawale, Sani Saidu, Yunusa O. Ibrahim, Maliha Abdullah Saleh Al Ghamdi, Sarah S. Aggad, Abdulrahman A. Alsayegh, Nada H. Aljarba, Gaber El-Saber Batiha, Alexander T.H. Wu, Hsu-Shan Huang
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Pulmeria alba methanolic extract
Streptozotocin
Dyslipidemia
Attenuation
Phytoconstituent
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223003700

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http://www.sciencedirect.com/science/article/pii/S0753332223003700

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