ROS-mediated lysosomal membrane permeabilization is involved in bupivacaine-induced death of rabbit intervertebral disc cells

Bupivacaine is frequently administered for diagnosing and controlling spine-related pain in interventional spine procedures. However, the potential cytotoxic effects of bupivacaine on intervertebral disc (IVD) cells and the underlying molecular mechanisms have not yet been fully established. Here, w...

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Bibliographic Details
Main Authors: Xianyi Cai, Yunlu Liu, Yiqiang Hu, Xianzhe Liu, Hongyan Jiang, Shuhua Yang, Zengwu Shao, Yun Xia, Liming Xiong
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718304385