Histone Demethylase JMJD3 Mediated Doxorubicin-Induced Cardiomyopathy by Suppressing SESN2 Expression

Histone Demethylase JMJD3 Mediated Doxorubicin-Induced Cardiomyopathy by Suppressing SESN2 Expression

Jumonji domain-containing 3 (JMJD3) protein, a histone demethylase protein, specifically catalyzes the demethylation of H3K27 (H3K27me3) and regulates gene expression. Sestrin2 (SESN2), a stress-inducible protein, protected against doxorubicin (DOX)-induced cardiomyopathy by regulating mitophagy and...

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Bibliographic Details
Main Authors: Panxia Wang, Rui Lan, Zhen Guo, Sidong Cai, Junjian Wang, Quan Wang, Zeyu Li, Zhenzhen Li, Qianqian Wang, Jingyan Li, Zhongkai Wu, Jing Lu, Peiqing Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
JMJD3
histone modification
SESN2
cardiotoxicity
H3K27me3
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.548605/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.548605/full

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