Conidial Melanin of the Human-Pathogenic Fungus <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Disrupts Cell Autonomous Defenses in Amoebae

Conidial Melanin of the Human-Pathogenic Fungus <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Disrupts Cell Autonomous Defenses in Amoebae

ABSTRACT The human-pathogenic fungus Aspergillus fumigatus is a ubiquitous saprophyte that causes fatal lung infections in immunocompromised individuals. Following inhalation, conidia are ingested by innate immune cells and can arrest phagolysosome maturation. How this virulence trait could have bee...

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Bibliographic Details
Main Authors: Iuliia Ferling, Joe Dan Dunn, Alexander Ferling, Thierry Soldati, Falk Hillmann
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mBio
Subjects:
Aspergillus fumigatus
Dictyostelium discoideum
Protostelium aurantium
DHN-melanin
phagocytosis
phagosome maturation
Online Access:https://journals.asm.org/doi/10.1128/mBio.00862-20

Internet

https://journals.asm.org/doi/10.1128/mBio.00862-20

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