Real-time molecular optical micro-imaging of EGFR mutations using a fluorescent erlotinib based tracer

Real-time molecular optical micro-imaging of EGFR mutations using a fluorescent erlotinib based tracer

Abstract Background EGFR mutations are routinely explored in lung adenocarcinoma by sequencing tumoral DNA. The aim of this study was to evaluate a fluorescent-labelled erlotinib based theranostic agent for the molecular imaging of mutated EGFR tumours in vitro and ex vivo using a mice xenograft mod...

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Bibliographic Details
Main Authors: Maxime Patout, Florian Guisier, Xavier Brune, Pierre Bohn, Anthony Romieu, Nasrin Sarafan-Vasseur, Richard Sesboüé, Pierre-Yves Renard, Luc Thiberville, Mathieu Salaün
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Pulmonary Medicine
Subjects:
Epidermal growth factor
EGFR
Molecular imaging
Lung cancer
Fibred confocal fluorescence microscopy
Erlotinib
Online Access:http://link.springer.com/article/10.1186/s12890-018-0760-z

Internet

http://link.springer.com/article/10.1186/s12890-018-0760-z

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