Interferon Lambda Signaling in Macrophages Is Necessary for the Antiviral Response to Influenza

Interferon Lambda Signaling in Macrophages Is Necessary for the Antiviral Response to Influenza

Interferon lambda (IFNλ) signaling is a promising therapeutic target against viral infection in murine models, yet little is known about its molecular regulation and its cognate receptor, interferon lambda receptor 1 (IFNLR1) in human lung. We hypothesized that the IFNλ signaling axis was active in...

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Bibliographic Details
Main Authors: Rama K. Mallampalli, Jessica Adair, Ajit Elhance, Daniela Farkas, Lexie Chafin, Matthew E. Long, Mithu De, Ana L. Mora, Mauricio Rojas, Victor Peters, Joseph S. Bednash, MuChun Tsai, James D. Londino
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
IFNLR1
interferon lambda
influenza
macrophage
lung
MCSF
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.735576/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.735576/full

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