Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis

Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis

Abstract We developed an on-slide decellularization approach to generate acellular extracellular matrix (ECM) myoscaffolds that can be repopulated with various cell types to interrogate cell-ECM interactions. Using this platform, we investigated whether fibrotic ECM scarring affected human skeletal...

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Bibliographic Details
Main Authors: Kristen M. Stearns-Reider, Michael R. Hicks, Katherine G. Hammond, Joseph C. Reynolds, Alok Maity, Yerbol Z. Kurmangaliyev, Jesse Chin, Adam Z. Stieg, Nicholas A. Geisse, Sophia Hohlbauch, Stefan Kaemmer, Lauren R. Schmitt, Thanh T. Pham, Ken Yamauchi, Bennett G. Novitch, Roy Wollman, Kirk C. Hansen, April D. Pyle, Rachelle H. Crosbie
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-023-00287-2

Internet

https://doi.org/10.1038/s41536-023-00287-2

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