Age-associated sperm DNA methylation patterns do not directly persist trans-generationally

Age-associated sperm DNA methylation patterns do not directly persist trans-generationally

Abstract Background The impact of aging on the sperm methylome is well understood. However, the direct, subsequent impact on offspring and the role of altered sperm DNA methylation alterations in this process remain poorly understood. The well-defined impact of aging on sperm DNA methylation represe...

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Bibliographic Details
Main Authors: Timothy G. Jenkins, Emma R. James, Kenneth I. Aston, Albert Salas-Huetos, Alexander W. Pastuszak, Ken R. Smith, Heidi A. Hanson, James M. Hotaling, Douglas T. Carrell
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Epigenetics & Chromatin
Online Access:https://doi.org/10.1186/s13072-019-0323-4

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https://doi.org/10.1186/s13072-019-0323-4

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