Circuit-based intervention corrects excessive dentate gyrus output in the fragile X mouse model

Abnormal cellular and circuit excitability is believed to drive many core phenotypes in fragile X syndrome (FXS). The dentate gyrus is a brain area performing critical computations essential for learning and memory. However, little is known about dentate circuit defects and their mechanisms in FXS....

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Bibliographic Details
Main Authors: Pan-Yue Deng, Ajeet Kumar, Valeria Cavalli, Vitaly A Klyachko
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-02-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/92563