Short-term hypoxia triggers ROS and SAFB mediated nuclear matrix and mRNA splicing remodeling

Short-term hypoxia triggers ROS and SAFB mediated nuclear matrix and mRNA splicing remodeling

The cellular response to hypoxia, in addition to HIF-dependent transcriptional reprogramming, also involves less characterized transcription-independent processes, such as alternative splicing of the VEGFA transcript leading to the production of the proangiogenic VEGF form. We now show that this eve...

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Bibliographic Details
Main Authors: Chrysa Taze, Sotiria Drakouli, Martina Samiotaki, George Panayotou, George Simos, Eleni Georgatsou, Ilias Mylonis
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Redox Biology
Subjects:
Hypoxia
Nuclear matrix
SAFB
Splicing
VEGFA
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722003172

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http://www.sciencedirect.com/science/article/pii/S2213231722003172

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