Development of D-α-Tocopherol polyethylene glycol 1000 succinate fabricated nanostructural lipid carrier of sorafenib tosylate for metastatic colorectal targeting application: Stability, physical characterization, cytotoxicity, and apoptotic studies against SW48 cells PTEN

Development of D-α-Tocopherol polyethylene glycol 1000 succinate fabricated nanostructural lipid carrier of sorafenib tosylate for metastatic colorectal targeting application: Stability, physical characterization, cytotoxicity, and apoptotic studies against SW48 cells PTEN

The study aimed to create D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) nanostructured lipid carriers (NLC) of sorafenib tosylate (ST) as lymphatic delivery systems (LDDS) to fight Metastatic colorectal cancer. Initially, ST-SLN, ST-NLC, and ST-LNE were formulated considering oleic acid (...

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Bibliographic Details
Main Authors: Sankha Bhattacharya, Satyam Sharma, Bhupendra G. Prajapati
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
sorafenib tosylate (ST)
SW48 Cells PTEN
apoptosis assay
colorectal cancer
D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS)
Nanostructural Lipid Carrier (NLC)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.990841/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.990841/full

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