Development of validated HPLC-UV method for simultaneous determination of Metformin, Amlodipine, Glibenclamide and Atorvastatin in human plasma and application to protein binding studies

Development of validated HPLC-UV method for simultaneous determination of Metformin, Amlodipine, Glibenclamide and Atorvastatin in human plasma and application to protein binding studies

A simple, sensitive, fast, and economical HPLC method was developed and validated for simultaneous estimation of two fixed dose combinations frequently prescribed in diabetes (Metformin plus Glibenclamide) and hypertension with dyslipidemia (Amlodipine plus Atorvastatin) in Human plasma for the firs...

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Bibliographic Details
Main Authors: Pawan K. Porwal, Gokul S. Talele
Format: Article
Language:English
Published: Faculty of Pharmacy, Cairo University 2017-06-01
Series:Bulletin of Faculty of Pharmacy Cairo University
Subjects:
Metformin
Glibenclamide
Amlodipine
Atorvastatin
HPLC-UV
Protein binding
Glycated human serum albumin
Online Access:http://www.sciencedirect.com/science/article/pii/S1110093116300345

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http://www.sciencedirect.com/science/article/pii/S1110093116300345

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