An Improved Genetically Encoded Fluorescent cAMP Indicator for Sensitive cAMP Imaging and Fast Drug Screening

An Improved Genetically Encoded Fluorescent cAMP Indicator for Sensitive cAMP Imaging and Fast Drug Screening

Cyclic adenosine 3′,5′-monophosphate (cAMP) is an important intracellular second messenger molecule downstream of many G protein-coupled receptors (GPCRs). Fluorescence imaging with bright and sensitive cAMP indicators allows not only dissecting the spatiotemporal dynamics of intracellular cAMP, but...

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Bibliographic Details
Main Authors: Wenfeng Liu, Chang Liu, Pei-Gen Ren, Jun Chu, Liang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
single-FP indicator
fluorescence imaging
circular permutation
cAMP
GPCR
drug discovery
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.902290/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.902290/full

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