Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation

Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation

The Transformics Assay is an in vitro test which combines the BALB/c 3T3 Cell Transformation Assay (CTA) with microarray transcriptomics. It has been shown to improve upon the mechanistic understanding of the CTA, helping to identify mechanisms of action leading to chemical-induced transformation th...

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Bibliographic Details
Main Authors: Gelsomina Pillo, Maria Grazia Mascolo, Cristina Zanzi, Francesca Rotondo, Stefania Serra, Francesco Bortone, Sandro Grilli, Monica Vaccari, Miriam N. Jacobs, Annamaria Colacci
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
transformics assay
cell transformation assay
transcriptomics
mechanistic understanding
chemical-induced transformation
enrichment analysis
Online Access:https://www.mdpi.com/1422-0067/23/14/7603

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https://www.mdpi.com/1422-0067/23/14/7603

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