Actin cytoskeleton depolymerization increases matrix metalloproteinase gene expression in breast cancer cells by promoting translocation of cysteine-rich protein 2 to the nucleus

Actin cytoskeleton depolymerization increases matrix metalloproteinase gene expression in breast cancer cells by promoting translocation of cysteine-rich protein 2 to the nucleus

The actin cytoskeleton plays a critical role in cancer cell invasion and metastasis; however, the coordination of its multiple functions remains unclear. Actin dynamics in the cytoplasm control the formation of invadopodia, which are membrane protrusions that facilitate cancer cell invasion by focus...

Full description

Bibliographic Details
Main Authors: Takouhie Mgrditchian, Joshua Brown-Clay, Céline Hoffmann, Tanja Müller, Liza Filali, Elena Ockfen, Xianqing Mao, Flora Moreau, Carla Pou Casellas, Tony Kaoma, Michel Mittelbronn, Clément Thomas
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Actin cytoskeleton
breast cancer
cysteine-rich protein 2 (CRP2)
gene transcription
matrix metalloproteinases (MMPs)
metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1100938/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1100938/full

Similar Items