DNA Methylation Analysis of Ribosomal DNA in Adults With Down Syndrome

DNA Methylation Analysis of Ribosomal DNA in Adults With Down Syndrome

Control of ribosome biogenesis is a critical aspect of the regulation of cell metabolism. As ribosomal genes (rDNA) are organized in repeated clusters on chromosomes 13, 14, 15, 21, and 22, trisomy of chromosome 21 confers an excess of rDNA copies to persons with Down syndrome (DS). Previous studies...

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Bibliographic Details
Main Authors: Francesco Ravaioli, Michele Zampieri, Luca Morandi, Chiara Pirazzini, Camilla Pellegrini, Sara De Fanti, Noémie Gensous, Gian Luca Pirazzoli, Luisa Sambati, Alessandro Ghezzo, Fabio Ciccarone, Anna Reale, Daniela Monti, Stefano Salvioli, Paola Caiafa, Miriam Capri, Alexander Bürkle, Maria Moreno-Villanueva, Paolo Garagnani, Claudio Franceschi, Maria Giulia Bacalini
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Genetics
Subjects:
Down syndrome
ribosomal genes
rDNA
aging
DNA methylation
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.792165/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.792165/full

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