Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer’s and Parkinson’s disease

Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer’s and Parkinson’s disease

Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) are involved in modulating cholinergic signaling, but their roles in Alzheimer’s and Parkinson’s diseases (AD and PD) remain unclear. We identified a higher frequency of the functionally impaired BCHE-K variant (rs1803274) in AD and PD c...

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Bibliographic Details
Main Authors: Muslum Gok, Nimrod Madrer, Tamara Zorbaz, Estelle R. Bennett, David Greenberg, David A. Bennett, Hermona Soreq
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Alzheimer’s disease
Parkinson’s disease
acetylcholinesterase
butyrylcholinesterase
SNPs (single-nucleotide polymorphisms)
splice variants
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.941467/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.941467/full

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