Protocol for pragmatic randomized clinical trial to evaluate the completion of treatment of latent Mycobacterium tuberculosis infection with Isoniazid in the 300 mg formulation.

Protocol for pragmatic randomized clinical trial to evaluate the completion of treatment of latent Mycobacterium tuberculosis infection with Isoniazid in the 300 mg formulation.

<h4>Introduction</h4>It is essential to strengthen the treatment of latent tuberculosis infection (LTBI) to break the chain of transmission. The drug used worldwide for the treatment of LTBI is Isoniazid. A clinical trial conducted in Brazil has demonstrated the bioequivalence of Isoniaz...

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Main Authors: João Paulo Cola, Thiago Nascimento do Prado, Bárbara Almeida Campos, Bárbara Juliana Pinheiro Borges, Bárbara Manuella Cardoso Sodré Alves, Sonia Vivian de Jezus, Carolina Maia Martins Sales, Wildo Navegantes de Araújo, Noemia Urruth Leão Tavares, Ethel Leonor Noia Maciel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0281638

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https://doi.org/10.1371/journal.pone.0281638

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