Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases
The mechanism by which DNA methylation might affect complex traits is not well understood. Here, the authors use Mendelian randomization to reveal a substantial role of transcript levels in mediating DNA methylation effects on complex traits and diseases.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35196-3 |
| _version_ | 1811188233461039104 |
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| author | Marie C. Sadler Chiara Auwerx Kaido Lepik Eleonora Porcu Zoltán Kutalik |
| author_facet | Marie C. Sadler Chiara Auwerx Kaido Lepik Eleonora Porcu Zoltán Kutalik |
| author_sort | Marie C. Sadler |
| collection | DOAJ |
| description | The mechanism by which DNA methylation might affect complex traits is not well understood. Here, the authors use Mendelian randomization to reveal a substantial role of transcript levels in mediating DNA methylation effects on complex traits and diseases. |
| first_indexed | 2024-04-11T14:16:08Z |
| format | Article |
| id | doaj.art-c2be3825597345b584bbf11cfe5a34d5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T14:16:08Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c2be3825597345b584bbf11cfe5a34d52022-12-22T04:19:25ZengNature PortfolioNature Communications2041-17232022-12-0113111410.1038/s41467-022-35196-3Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseasesMarie C. Sadler0Chiara Auwerx1Kaido Lepik2Eleonora Porcu3Zoltán Kutalik4University Center for Primary Care and Public HealthUniversity Center for Primary Care and Public HealthUniversity Center for Primary Care and Public HealthUniversity Center for Primary Care and Public HealthUniversity Center for Primary Care and Public HealthThe mechanism by which DNA methylation might affect complex traits is not well understood. Here, the authors use Mendelian randomization to reveal a substantial role of transcript levels in mediating DNA methylation effects on complex traits and diseases.https://doi.org/10.1038/s41467-022-35196-3 |
| spellingShingle | Marie C. Sadler Chiara Auwerx Kaido Lepik Eleonora Porcu Zoltán Kutalik Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases Nature Communications |
| title | Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases |
| title_full | Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases |
| title_fullStr | Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases |
| title_full_unstemmed | Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases |
| title_short | Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases |
| title_sort | quantifying the role of transcript levels in mediating dna methylation effects on complex traits and diseases |
| url | https://doi.org/10.1038/s41467-022-35196-3 |
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